| 芳香化酶抑制剂来曲唑的研究进展 |
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| 引用本文： | 祝鸿,徐进宜,吴晓明. 芳香化酶抑制剂来曲唑的研究进展[J]. 海峡药学, 2004, 16(4): 1-5 |
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| 作者姓名： | 祝鸿 徐进宜 吴晓明 |
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| 作者单位： | 中国药科大学药物化学教研室,南京,210009;中国药科大学药物化学教研室,南京,210009;中国药科大学药物化学教研室,南京,210009 |
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| 摘 要： | 来曲唑是新一代强效的非甾体芳香化酶抑制剂，用于一线治疗晚期乳腺癌，并广泛用作乳腺癌的二线用药．疗效好，不良反应少，耐受性好．值得临床推广应用。本文综述了来曲唑的合成方法以及临床研究进展。
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| 关 键 词： | 来曲唑 芳香化酶抑制剂 乳腺癌 |
| 文章编号： | 1006-3765(2004)04-0001-05 |
Recent Advances of Aromatase Inhibitor Letrozole |
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| ZHU Hong,XU Jin-yi,WU Xiao-ming. Recent Advances of Aromatase Inhibitor Letrozole[J]. Strait Pharmaceutical Journal, 2004, 16(4): 1-5 |
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| Authors: | ZHU Hong XU Jin-yi WU Xiao-ming |
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| Affiliation: | ZHU Hong,XU Jin-yi,WU Xiao-ming * |
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| Abstract: | Letrozole is a novel potent nonsteroidal aromatase inhibitor,which has been shown to be useful as first-line therapy in postmenopausal women with advanced breast cancer(ABC).It was well tolerated and produced potent,selective and long-lasting inhibition of aromatase.Letrozole is an effective and safe agent for treatment of ABC.The advances in the research of the synthesis and clinical studies of Letrozole were reviewed in this paper. |
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| Keywords: | Letrozole Aromatase inhibitors Advanced breast cancer |
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