琥珀酸氢化考的松治疗药物性肝损害疗效分析

目的：观察琥珀酸氢化考的松治疗药物性肝损害的疗效。方法：2005年1月-2005年12月本院收治药物性肝损害患者共97例，入院第一周给予一般性治疗，包括停用可疑药物，补充葡萄糖、维生素、门冬酸钾镁和还原型谷胱甘肽，其中63例肝功能逐渐恢复，而34例患者肝功能无改善甚至有不同程度恶化，此时除上述一般性治疗外同时给予静滴琥珀酸氢化考的松共9天。结果：使用琥珀酸氢化考的松后34例患者肝功能明显改善，临床症状好转。结论：药物性肝损害经及时停药、保肝等对症治疗后，大部分能恢复正常，而肝损害严重者正确使用琥珀酸氢化考的松能有效减轻临床症状、改善肝功能、缩短病程。

Observation on the efficacy of hydrocortisone for the treatment of drug-induced liver injury

Objective:To observe the efficacy of hydrocortisone for the treatment of drug-induced liver injury (DILI).Methods: There are 97 patients with drug-induced liver injury in our hospital from January to December in 2005.At first week the patients with DILI were given unclassified therapeutic measures including drug withdrawal,and adding glucose,vitamin,potassium magnesium and glutathione.Among them,63 patients' conditions were improving gradually while 34 patients' conditions had no amelioration and even got worse.At this time hydrocortisone was given to them daily for 9 days.Results:Liver function of the 34 patients was improving gradually as same as clinical symptom.Conclusion:Hydrocortisone can effectually relieve clinical symptom,improve liver function and shorten course of disease.