Reduced referral and case fatality rates for severe symptomatic hyperlactataemia in a South African public sector antiretroviral programme: a retrospective observational study |
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| Authors: | Charlotte Schutz Andrew Boulle Dave Stead Kevin Rebe Meg Osler Graeme Meintjes |
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| Affiliation: | (1) Infectious Diseases Unit, GF Jooste Hospital, Duinefontein Road, Manenberg, 7764, Cape Town, South Africa;(2) Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, South Africa;(3) School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, South Africa;(4) Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, South Africa |
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| Abstract: | Background Interventions to promote prevention and earlier diagnosis of severe symptomatic hyperlactataemia (SHL) were implemented in the Western Cape provincial antiretroviral programme (South Africa) from 2004. Interventions included clinician education, point-of-care lactate meters, switch from stavudine to zidovudine in high risk patients and stavudine dose reduction. This study assessed trends in referral rate, severity at presentation and case fatality rate for severe SHL. |
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