Association between anthropometric measures of obesity and subclinical atherosclerosis in Bangladesh |
| |
Authors: | Wenzhen Ge Faruque Parvez Fen Wu Tariqul Islam Alauddin Ahmed Ishrat Shaheen Golam Sarwar Ryan T. Demmer Moise Desvarieux Habibul Ahsan Yu Chen |
| |
Affiliation: | 1. Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA;2. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York City, NY, USA;3. Columbia University Arsenic Research Project, Dhaka, Bangladesh;4. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA;5. INSERM, UMR-S 707, Université Pierre et Marie Curie-Paris 6, Paris, France;6. École des Hautes Études en Santé Publique, Paris and Rennes, France;g Department of Health Studies, The University of Chicago, Chicago, IL, USA;h Department of Medicine, The University of Chicago, Chicago, IL, USA;i Department of Human Genetics, The University of Chicago, Chicago, IL, USA;j Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA |
| |
Abstract: | BackgroundAnthropometric measures such as waist–hip-ratio (WHR), waist-height-ratio (WHtR), waist circumference, Mid-upper arm circumference (MUAC), and upper thigh circumference, have been linked to the risk of cardiovascular disease (CVD). However, their relationships with subclinical atherosclerosis are unclear. Studies in normal-weight populations, especially in Asian countries where leanness is prevalent, are lacking.MethodsWe conducted a cross-sectional study to assess the associations of WHR, WHtR, waist circumference, hip circumference, body mass index (BMI), MUAC and upper thigh circumference with carotid intima-media thickness (cIMT) among 562 middle-aged participants free of CVD in rural Bangladesh.ResultsAfter adjusting for age and sex, WHR and waist circumference but not BMI showed a positive significant association with cIMT. In multivariate analysis, each standard deviation (SD) increase of WHR (0.08) or WHtR (0.07) was associated with an 8.96 μm (95% CI, 1.12–16.81) or 11.45 μm (95%CI, 0.86–22.04) difference in cIMT, respectively, after controlling for age, sex, BMI, smoking status, education level, and systolic blood pressure (SBP). The associations of WHR and WHtR with cIMT were independent of the influence of other anthropometric measures. The associations of other anthropometric measures and cIMT were not apparent.ConclusionsIn our relatively lean, healthy Asian population, WHR and WHtR appear to be better predictors of early atherosclerosis than other common surrogates of adiposity. |
| |
Keywords: | Preclinical atherosclerosis Carotid intima-media thickness (cIMT) Anthropometric measures Waist&ndash hip-ratio (WHR) |
本文献已被 ScienceDirect 等数据库收录! |
|