Contemporary analysis of pelvic and para-aortic metastasis in endometrial cancer using the SEER registry |
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Authors: | Evangelia Katsoulakis Malcolm D. Mattes Justin M. Rineer Thomas Nabhani Waleed F. Mourad Kwang Choi David Schreiber |
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Affiliation: | 1. Department of Radiation Oncology, New York Methodist Hospital, New York, NY, USA;2. Department of Radiation Oncology, MD Anderson Cancer Center Orlando, Orlando, FL, USA;3. Department of Radiation Oncology, State University of New York-Downstate, New York, NY, USA;4. Department of Radiation Oncology, Beth Israel Medical Center, New York, NY, USA;5. Department of Veterans Affairs, New York Harbor Healthcare System, New York, NY, USA |
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Abstract: | ObjectiveTo determine the incidence of regional lymph node involvement for early-stage endometrial cancer by using the Surveillance, Epidemiology, and End Results (SEER) registry.MethodsIn a retrospective study, data were analyzed from patients who were diagnosed with stage IA–IIB endometrioid adenocarcinoma and were treated between 1998 and 2003. The incidence of pelvic and para-aortic lymph node involvement was determined.ResultsData were analyzed from 4052 patients. Incidences of pelvic and para-aortic lymph node metastases were: 1% and 0% in stage IA, grade 1 disease; 2% and 0% in IA, grade 2; 2% and 1% in IA, grade 3; 2% and 0% in IB, grade 1; 3% and 1% in IB, grade 2; 3% and 2% in IB, grade 3; 7% and 3% in IC, grade 1; 8% and 5% in IC, grade 2; 12% and 8% in IC, grade 3; 7% and 3% in IIA, grade 1; 10% and 4% in IIA, grade 2; 10% and 5% in IIA, grade 3; 8% and 4% in IIB, grade 1; 13% and 8% in IIB, grade 2; and 19% and 12% in IIB, grade 3.ConclusionIncidences of pelvic and para-aortic metastases were lower than previously reported. Patients at higher stages and grades had a 10% or higher risk of lymph node involvement and might benefit from aggressive therapy. |
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Keywords: | Endometrial cancer Lymph node Metastasis Surveillance, Epidemiology, and End Results (SEER) registry Staging |
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