Undercarboxylated osteocalcin relates to cardiovascular risk markers in offspring of families with metabolic syndrome |
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| Authors: | Anna Prats-Puig Inés Osiniri Pilar Soriano-Rodríguez Gemma Carreras-Badosa José Cristóbal Buñuel-Álvarez Carmen Vila-Pablos Francis de Zegher Lourdes Ibáñez Judit Bassols Abel López-Bermejo |
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| Institution: | 1. Pediatrics Research Group, Girona Institute for Biomedical Research, 17007 Girona, Spain;2. Pediatrics, Dr. Josep Trueta Hospital, 17007 Girona, Spain;3. Pediatrics, Salut Empordà Foundation, 17600 Figueres, Spain;4. Clinical Laboratory, Salut Empordà Foundation, 17600 Figueres, Spain;5. Primary Care Pediatrics, Catalonian Institute of Health, 17007 Girona, Spain;6. Department of Development & Regeneration, University of Leuven, 3000 Leuven, Belgium;g Pediatric Endocrinology, Sant Joan de Déu Children''s Hospital, 08950 Esplugues, Barcelona;h CIBERDEM (Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders), ISCIII, 28029 Madrid, Spain;i TransLab Research Group, Department of Medical Sciences, Faculty of Medicine, University of Girona, 17071 Girona, Spain |
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| Abstract: | BackgroundThe undercarboxylated form of osteocalcin (ucOC) is an emerging marker of cardiovascular disease. It is unknown if ucOC in related to common cardiovascular risk markers in children. In offspring of families with and without metabolic syndrome (MetS+ and MetS− families), we assessed whether ucOC was related to a continuous metabolic syndrome score (MetS score) and to carotid intima–media thickness (cIMT).MethodsucOC and total OC, MetS score and cIMT were assessed in 203 asymptomatic prepubertal children (age 7.6 ± 0.1 yr; 49% girls), of whom 99 were from MetS+ families.ResultsIn children from MetS+ families, percent ucOC was higher than in children from MetS− families (p < 0.01). In offpring from MetS+ families, higher ucOC and especially higher percent ucOC was independently associated with both the MetS score and cIMT (both p ≤ 0.01).ConclusionsThe undercarboxylated form of OC is related to common cardiovascular risk markers in children at risk for cardiovascular disease. |
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| Keywords: | Intima&ndash media thickness Osteocalcin Children Metabolic syndrome |
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