| 谷胱甘肽的耗竭与肿瘤细胞凋亡 |
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| 引用本文： | 王静丽,赵临襄,景永奎. 谷胱甘肽的耗竭与肿瘤细胞凋亡[J]. 中国药物化学杂志, 2003, 13(6): 361-366 |
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| 作者姓名： | 王静丽 赵临襄 景永奎 |
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| 作者单位： | 1. 沈阳药科大学制药工程学院,辽宁,沈阳,110016
2. Mount Sinai School of Medicine New York,10029-6574,USA |
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| 基金项目： | 国家自然科学基金资助项目 ( 30 1710 99)，辽宁省自然科学基金项目 ( 2 0 0 2 10 5 2 ) |
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| 摘 要： | 细胞凋亡是由一系列基因控制的细胞主动死亡过程，凋亡的通路受到抑制是肿瘤产生的重要原因。凋亡机制的最新研究发现细胞内谷胱甘肽(GSH)的水平与细胞凋亡密切相关。通过GSH的耗竭可以启动肿瘤细胞凋亡。本文综述了GSH的耗竭诱导肿瘤细胞凋亡的分子生物学机制、GSH耗竭剂——GSH合成抑制剂与GSH结合剂的研究进展以及GSH耗竭剂作为肿瘤细胞凋亡诱导剂的应用前景。
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| 关 键 词： | 药物化学 研究进展 综述 肿瘤细胞凋亡 GSH的耗竭 凋亡诱导剂 |
| 文章编号： | 1005-0108(2003)06-0361-06 |
Depletion of glutathione and the apoptosis of tumor cells |
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| WANG Jing li ,ZHAO Lin xiang ,JING Yong kui. Depletion of glutathione and the apoptosis of tumor cells[J]. Chinese Journal of Medicinal Chemistry, 2003, 13(6): 361-366 |
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| Authors: | WANG Jing li ZHAO Lin xiang JING Yong kui |
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| Affiliation: | WANG Jing li 1,ZHAO Lin xiang 1,JING Yong kui 2 |
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| Abstract: | Apoptosis is a form of programmed cell death,in the cells it commits suicide following a defined set of cellular responses.It is believed that the increased resistance to apoptosis of tumor cells is one of the underlying molecular reasons contributing to tumor progression.Apoptosis can be induced or trigged by a variety of stimuli,including depletion of reduced glutathione(GSH).The possibility of selectively inducing the depletion of GSH in tumor cells,the transduction mechanism of apoptosis signals and the development of inducers of apoptosis by GSH depleting are reviewed in this article. |
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| Keywords: | medicinal chemistry research progress review apoptosis glutathione depletion apoptosis inducers |
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