| 硫代脯氨酸的毒性研究 |
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| 引用本文： | 黄永真,万纯,陈斌.硫代脯氨酸的毒性研究[J].宜春医专学报,1996(Z2). |
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| 作者姓名： | 黄永真 万纯 陈斌 |
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| 作者单位： | 营卫教研室，袁州医院，生物化学教研室 宜春 336000，宜春 336000，宜春 336000 |
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| 摘 要： | 本文对硫代脯氨酸(Thioproline)的毒性进行了初步研究。结果表明:小白鼠一次经口的LD_(50)为276.06mg/kg;亚急性毒性试验提示在50～200mg/kg范围内对大白鼠无明显毒性;小白鼠骨髓PCE微核试验结果也显示对小鼠无致突变作用。实验表明,硫代脯氨酸属于中毒化合物,在正常使用剂量范围内对大、小鼠均无明显毒作用。
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| 关 键 词： | 硫代脯氨酸 毒性 微核 |
A Toxic Study on Thioproline |
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| Huang Yongzhen,et al.A Toxic Study on Thioproline[J].Journal of Yichun Medical College,1996(Z2). |
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| Authors: | Huang Yongzhen |
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| Institution: | Department of Nutrition and Food Hygiene |
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| Abstract: | This paper studied the toxicity of thioproline primaryly. The results showed that LD50 of micewere 276. 06mg per kg;Short term toxicity test showed that it has no significant toxicity between 50 and 200 mg per kg;mini-caryon tests of marrow PCE showed that it has no mutagenicity effect about mice yet. The conclusion was that thioproline belongs to poisoned-compound. No significant toxic effect in rats and mice were found by normal dose. |
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| Keywords: | Thoproline toxicity mini-caryon |
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