B-cell epitopes of varicella-zoster virus glycoprotein II |
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Authors: | A. Kjartansdóttir E. Lycke S. R. Norrby |
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Affiliation: | (1) Departments of Infectious Diseases and Medical Microbiology, Lund University, Lund, Sweden |
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Abstract: | Summary B-cell epitopes of varicella-zoster virus glycoprotein II were mapped by means of solid phase ELISA, synthetic oligopeptides (constructed according to the Davison-Scott sequencing of the varicella-zoster virus genome) and sera from varicellae and herpes zoster patients. The individual pattern of antibody peptide binding varied considerably but at least 9 more reactive sites seemed discernible. A 31-mer-peptide corresponding to a hydrophilic segment of the glycoprotein (aa 417–447) was constructed. This peptide reacted with 2 out of 4 varicellae and 5 out of 9 zoster sera, respectively. |
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