未折叠蛋白反应参与胰腺癌化疗耐药研究进展

化疗耐药是导致胰腺癌预后不良的重要因素,耐药形成受多种因素调控,其中包括内质网应激(endoplasmic reticulum stress,ERS)状态下的未折叠蛋白反应(unfolded protein response, UPR)。UPR通过参与化疗药物外排、自噬、上皮-间充质转化和肿瘤干细胞形成等过程, 最终导致胰腺癌耐药。本文综述了近年来未折叠蛋白反应在胰腺癌耐药过程中的作用机制,旨在为改善胰腺癌不良预后提供参考。

Study on the Policy and Application of Cloud Migration in Chinese Hospitals

Objective/Significance To summarize the relevant policies, practical applications and promotion effects of hospital information systems (HIS) on the cloud in China, to analyze national policy orientation and application status, so as to put forward reasonable proposals on the next action and promotion strategy.Method/Process Relevant policy documents and applications of HIS on the cloud are retrieved from national and provincial government websites in China,and the policy development rules and opportunities and challenges faced are summarized.Relevant articles published from 2010 to 2023 are searched on CNKI to summarize the concrete practice of HIS on the cloud.Result/Conclusion It is suggested that hospitals with existing conditions can make full use of the current national policy dividend and actual business expansion needs to migrate to the cloud as soon as possible, and relevant departments should also issue more targeted development strategies and supporting implementation guidelines to specifically guide hospitals to migrate to the cloud scientifically, effectively and safely, so as to accelerate the generation of new forms of medical industry and fully meet the needs of public health care in the new era.