眼底血管改变与脑白质高信号的相关性分析

目的 探讨眼底血管改变与脑白质高信号（white matter hypertensity,WMH）的相关性。方法 选取2022年7月至2023年7月于衢州市人民医院神经内科确诊的87例WMH患者作为实验组，同期随机选择80例年龄相匹配的无WMH的健康体检者作为对照组。应用光学相干断层扫描（optical coherence tomography,OCT）及光学相干断层扫描血管成像（optical coherence tomography angiography,OCTA）技术测量两组入选者的视网膜血管结构、微血管密度和神经纤维层（retinal nerve fiber layer,RNFL）厚度等眼底血管参数，比较两组的差异并分析其相关性。结果 与对照组比较，实验组患者的视网膜血管结构和微血管密度参数与WMH无相关性。平均、颞上部、鼻下部RNFL厚度减少（P<0.05）。结论 OCT与OCTA检测WMH均具有可行性，颞上部、鼻下部视网膜神经纤维层厚度可作为预测WMH发生风险的指标之一。

Correlation analysis between retinal vascular changes and white matter hyperintensity

Objective To investigate the correlation between retinal vascular changes and patients with white matter hyperintensity (WMH). Methods A total of 87 patients diagnosed with WMH in the Department of Neurology, Quzhou People''s Hospital, from July 2022 to July 2023 were selected as experimental group. Concurrently, 80 age-matched healthy individuals without WMH undergoing regular health check-ups were randomly selected as control group. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) technologies were applied to measure retinal vascular parameters, including vascular structure, microvascular density, and retinal nerve fiber layer (RNFL) thickness. Compare the differences between two groups and analyze their correlation. Results Compared with the control group, the experimental group exhibited no correlation between retinal vascular structure and microvascular density parameters with WMH. However, there was a significant decrease in average, temporal upper, and nasal lower RNFL thickness (P<0.05). Conclusion OCT and OCTA are feasible methods for detecting WMH, and the thickness of the temporal upper and nasal lower retinal nerve fiber layers can serve as indicators for predicting the risk of WMH occurrence.