| 河南省低中度氟暴露地区成年男性骨密度的影响因素分析 |
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| 作者姓名： | 王晨曦 张洛铭 樊晓晨 姜楠 杜亚哲 马奔丽 孙仁杰 左其亭 周郭育 巴月 |
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| 作者单位： | 郑州大学公共卫生学院预防医学系;开封市疾病预防控制中心地方病科;郑州大学公共卫生学院环境卫生学教研室;郑州大学黄河生态保护与区域协调发展研究院 |
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| 基金项目： | 国家自然科学基金(81972981);郑州大学大学生创新创业训练计划项目(2020cxcy555);郑州大学教学改革研究与实践项目(2020zzuJXLX003)。 |
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| 摘 要： | 目的:探索河南省低中度氟暴露地区成年男性骨密度的影响因素。方法:采用整群随机抽样方法，于2017年4-5月选择河南省开封市通许县低中度氟暴露地区的成年男性村民为调查对象。通过问卷调查、体格测量获得调查对象的基本人口学资料，并收集晨尿样本。采用离子选择电极法测定尿氟含量，使用超声波骨密度仪测量骨密度（以T值表示），利用偏...
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| 关 键 词： | 氟化物 男性 骨密度 |
Bone mineral density in adult males: multi-factors analysis in the low-to-moderate fluoride exposure areas of Henan Province |
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| Authors: | Wang Chenxi Zhang Luoming Fan Xiaochen Jiang Nan Du Yazhe Ma Benli Sun Renjie Zuo Qiting Zhou Guoyu Ba Yue |
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| Institution: | (Department of Preventive Medicine,School of Public Health,Zhengzhou University,Zhengzhou 450001,China;Department of Endemic Disease,Center for Disease Prevention and Control of Kaifeng,Kaifeng 475004,China;Department of Environmental Health,Environment and Health Innovation Team,School of Public Health,Zhengzhou University,Zhengzhou 450001,China;Institute for Yellow River Ecology Protection&Regional Coordination Development,Zhengzhou University,Zhengzhou 450001,China) |
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| Abstract: | Objective To explore the factors affecting bone mineral density(BMD)in adult males with low-to-moderate fluoride exposure in Henan Province.Methods Adult male villagers from low-to-moderate fluoride exposure areas in Tongxu County,Kaifeng City,Henan Province were recruited from April to May 2017 based on cluster random sampling.Questionnaire survey,physical measurements and urinary samples collection were conducted respectively.Urinary fluoride(UF)was determined by fluoride ion-selective electrode.Ultrasound bone densitometer was used to measure BMD(T-score).Partial correlation analysis and multiple linear regression were used to analyze the influence factors of BMD.Results A total of 439 adult males were included in this study.Age,body mass index(BMI),UF content,and T-score of the participants were(47.99±8.49)years,(25.77±3.23)kg/m2,(1.34±0.74)mg/L,and-1.79±0.79,respectively.Partial correlation analysis showed a significantly positive correlation between BMI and T-score after age adjustment(r=0.194,P<0.05).Multiple linear regression showed that T-score decreased by 0.015(95%CI:-0.024--0.005,P<0.05)for each 1-year increase in age and T-score increased by 0.034(95%CI:0.009-0.059,P<0.05)for each 1.0 kg/m2 increase in BMI.Interaction analysis showed that T-score was closely related to the interaction between overweight(≥24.0 kg/m2),non-smoking,tea drinking and UFβ(95%CI):0.134(0.001-0.269),0.163(-0.015-0.337),0.215(-0.006-0.436),P<0.10].Conclusions Our findings reveal a negative correlation between age and BMD,and a positive correlation between BMI and BMD in adult males with low-to-moderate fluoride exposure in Henan Province.In addition,low-to-moderate fluoride exposure is more likely to damage the BMD of smokers. |
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| Keywords: | Fluorides Male Bone mineral density |
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