双C治疗减轻重度颅脑损伤患者血糖波动与预后相关性

目的 观察双C治疗减轻重度颅脑损伤患者血糖波动与预后相关性.方法 2016年10月—2019年9月住院的94例重度颅脑损伤合并高血糖患者随机分为两组,治疗组给予双C治疗(动态血糖仪+胰岛素泵),对照组给予常规胰岛素强化治疗,在三餐前血糖达标后,以动态血糖仪监测血糖,计算平均血糖波动幅度(mean amplitude o...

Study on the Correlation Between Blood Glucose Fluctuation and Prognosis in Patients With Severe Craniocerebral Injury Treated With Double C

Objective Observe the correlation between blood glucose fluctuation and prognosis in patients with severe craniocerebral injury treated with double C.Methods From October 2016 to September 2019,94 patients with severe craniocerebral injury with hyperglycemia were randomly divided into 2 groups,treatment group recieved double C(dynamic glucose meter+insulin pump),the control group recieved conventional insulin intensive treatment,after the blood glucose control reached at target before meals,the blood glucose was monitored by dynamic glucose meter,the average blood glucose fluctuation(mean amplitude of glycemic excursions,MAGE)was calculated,compared two groups of hospitalization days,mechanical ventilation time and mortality rate,infection rate,incidence of hypoglycemia,Glasgow coma scale(GCS scale).Results The MAGE in the treatment group was significantly lower than the control group,the duration of mechanical ventilation was significantly shorter in the treatment group than in the control group,the mortality rate was significantly lower,and the Glasgow coma score was significantly lower on a scale of 3~5.Conclusion Double C treatment can reduce the fluctuation of blood glucose in patients with severe craniocerebral injury combined with hyperglycemia,thus shorten the time of mechanical ventilation,reduce the mortality rate and improve the prognosis of patients.