桂枝茯苓胶囊联合新生化颗粒用于妊娠10～16周药物流产95例

目的观察桂枝茯苓胶囊联合新生化颗粒用于妊娠10～16周药物流产的临床疗效和安全性。方法将妊娠10～16周自愿要求终止妊娠的285例孕妇随机分为3组(A组、B组和C组),每组95例。所有患者均予以米非司酮联合米索前列醇的药物流产(药流)方案,A组在药流的第1天加服新生化颗粒(2袋,tid,po),B组在药流的第1天加服桂枝茯苓胶囊(3粒,tid,po),C组在药流的第1天加服新生化颗粒(2袋,tid,po)和桂枝茯苓胶囊(3粒,tid,po),3组均连续用药7 d。比较3组完全流产率、不完全流产率、流产失败率、不良反应发生率、胚胎排出时间、阴道流血时间、阴道流血量、月经复潮时间、血红蛋白变化值。结果 A、B、C组完全流产率分别为71.58%,68.42%,90.53%,C组完全流产率显著大于A组和B组(P<0.05),不完全流产率、流产失败率、血红蛋白下降值、胚胎排出时间、阴道出血时间、月经复潮时间和阴道出血量均小于A组和B组(P<0.05),A组和B组间差异无统计学意义(P>0.05)。3组均未发生严重不良反应。结论桂枝茯苓胶囊联合新生化颗粒能显著提高药流的完全流产率...

Effect of Guizhifuling Capsule Combined with Xinshenghua Granule on Medical Abortion in the Treatment of 95 Patients at 10-16 Weeks Pregnancy

Objective To analysis the efficacy and safety of guizhifuling capsule combined with xinshenghua granule for medical abortion at 10-16 weeks pregnancy.Methods A total of 285 patients with pregnancy of 10-16 weeks who voluntary requested for termination of pregnancy were randomly divided into three groups(group A,B and C,95 cases in each group).All patients were treated with a medical abortion with mifepristone and misoprostol,group A was added xinshenghua granule(2 packs per time,tid,po)on the first day of drug flow,group B was added guizhifuling capsule(3 capsules per time,tid,po)on the first day of drug flow,and group C was added xinshenghua granule(2 packs per time,tid,po)and guizhifuling capsule(3 capsules per time,tid,po)on the first day of drug treatment,three groups were treated continuously for 7 days.The three groups were compared with complete abortion rate,incomplete abortion rate,abortion failure rate,ADR rate,embryo discharge time,vaginal bleeding time,vaginal bleeding,menstrual re-tidal time and hemoglobin change value.Results The rates of complete abortion in group A,B and C were 71.58%,68.42%and 90.53%,respectively.The complete abortion rate of group C significantly greater than group A and group B.The incomplete abortion rate,abortion failure rate,hemoglobin decline,embryo discharge time,vaginal bleeding time,vaginal bleeding,menstrual re-tidal time,and vaginal bleeding of group C were significantly lower than group A and group B(P<0.05).However,there is no significant difference in those aspects between group A and B(P>0.05).No serious ADR occurred in all three groups,and there was no significant difference in ADR(P>0.05).Conclusion Guizhifuling capsule combined with xinshenghua granule is beneficial to improve the complete abortion rate of mifepristone and misoprostol medicinal abortion;shorten the discharge time of gestational sac,vaginal bleeding time,and menstrual rewet time;and reduce the amount of bleeding.and no increase the incidence of adverse reactions.It is worthy to clinical promotion.