婴儿及儿童原发性心脏肿瘤21例临床分析

目的:总结婴儿及儿童原发性心脏肿瘤的临床特点、治疗方法及预后。方法:回顾性分析2010年5月至2018年8月在首都医科大学附属北京安贞医院小儿心脏中心诊断为原发性心脏肿瘤的21例患儿的临床资料，其中男10例，女11例；中位年龄7个月(胎龄26周～15岁，其中6例胎儿期发现)，总结21例患儿的临床特点、治疗方法及预后。结...

Clinical analysis of 21 primary cardiac tumors in infants and children

Objective To explore the clinical characteristics,treatment and prognosis of primary cardiac tumors in infants and children.Methods The clinical information for 21 patients with primary cardiac tumor in the Department of Pediatric Cardiology,Beijing Anzhen Hospital Affiliated to Capital Medical University from May 2010 to August 2018 were analyzed retrospectively.Their median age was 7 months(gestational age 26 weeks-15 years old,and 6 cases were found in fetal phase)and 10 cases of them were male,11 cases were girl.The clinical features,treatment methods and prognosis were summarized.Results Among the 21 patients,8 cases had an atypical heart murmur,2 cases with chest tightness and chest pain,2 cases with congestive heart failure,1 case with dizziness and amaurosis,1 case with cerebral artery embolism,1 case with higher inflammatory index,and 9 cases were asymptomatic.Totally,13 cases underwent surgical resection.All of them were confirmed as benign tumors,including 4 cases of rhabdomyoma,3 cases of myxoma,3 cases of fibroma and 2 cases of inflammatory myofibroblastic tumor(IMT)and 1 case of teratomas.There was no death during perioperative period.Follow-ups were performed from 3 months to 7 years,and 3 cases had recu-rrence(2 cases with myxomas and 1 cases with IMT).There were 8 cases without treatment,of which 7 cases were clinically diagnosed as transverse leiomyoma.During the follow-up,3 cases disappeared,1 case became small,2 cases had no obvious change,and 1 case was lost to follow-up.One case was considered to be malignant tumor,and died within half a year.Conclusions Primary cardiac tumors in children are mostly benign,especially transverse leiomyoma,and their clinical manifestations are diverse.Pathological examination is the golden standard for diagnosis.Surgical treatment is a radical method for most cardiac tumors,some benign tumors can be treated with drug adjuvant therapy,while the prognosis is poor for malignant cardiac tumor patients.