| GABA_A受体转运及其在神经性疾病中的作用 |
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| 引用本文： | 李翠限,王莹,周春,沈晓燕. GABA_A受体转运及其在神经性疾病中的作用[J]. 中国药理学通报, 2011, 27(7): 889-892. DOI: 10.3969/j.issn.1001-1978.2011.07.001 |
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| 作者姓名： | 李翠限 王莹 周春 沈晓燕 |
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| 作者单位： | 中山大学药学院药理毒理学实验室,广东,广州,510006 |
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| 基金项目： | 国家自然科学基金资助项目，教育部高等学校博士学科点专项科研基金博导项目，广东省科技厅资助项目 |
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| 摘 要： | γ-氨基丁酸A型受体(GABAARs)是配体门控离子通道超家族的成员之一,介导哺乳动物大脑中大多数的快速型突触抑制。该文对促使GABAAR运转的相关蛋白,内吞和内吞后的分拣过程,以及癫痫和精神分裂症等神经系统疾病中发生的GABAAR的转运改变进行讨论。
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| 关 键 词： | γ-氨基丁酸A型受体 转运 内吞 再循环 GABAA受体相关蛋白 神经性疾病 |
Transportation and role of GABAA receptor in neurological diseases |
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| LI Cui-xian,WANG Ying,ZHOU Chun,SHEN Xiao-yan. Transportation and role of GABAA receptor in neurological diseases[J]. Chinese Pharmacological Bulletin, 2011, 27(7): 889-892. DOI: 10.3969/j.issn.1001-1978.2011.07.001 |
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| Authors: | LI Cui-xian WANG Ying ZHOU Chun SHEN Xiao-yan |
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| Affiliation: | LI Cui-xian,WANG Ying,ZHOU Chun,SHEN Xiao-yan (Dept of Pharmacology and Toxicology,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China) |
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| Abstract: | GABA(γ-aminobutyric acid) type A receptors(GABAARs) are part of a ligand-gated ion-channel superfamily.They mediate most fast synaptic inhibition in the mammalian brain.In this paper,we discuss recent progress in our understanding of the proteins facilitating GABAAR transportation,endocytosis and post-endocytic GABAAR sorting,and a number of neurological disorders,including epilepsy and schizophrenia,in which alterations in GABAAR transportation occur. |
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| Keywords: | γ-aminobutyric acid type A receptors(GABAARs) transportation endocytosis recirculation GABAA receptor-associated protein neurogenic disease |
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