| 万古霉素单用及联合利福平或磷霉素对耐甲氧西林金黄色葡萄球菌防耐药突变浓度的研究 |
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| 引用本文： | 梅清,喻婷,朱玉林,程君,叶英,李家斌. 万古霉素单用及联合利福平或磷霉素对耐甲氧西林金黄色葡萄球菌防耐药突变浓度的研究[J]. 中国药理学通报, 2011, 27(7): 944-947. DOI: 10.3969/j.issn.1001-1978.2011.07.014 |
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| 作者姓名： | 梅清 喻婷 朱玉林 程君 叶英 李家斌 |
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| 作者单位： | 1. 安徽医科大学第一附属医院感染科,安徽,合肥,230022
2. 安徽医科大学第一附属医院感染科,安徽,合肥,230022;安徽省细菌耐药监测中心,安徽,合肥,230022;安徽医科大学细菌耐药研究所,安徽,合肥,230022 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的在体外探讨万古霉素单用及其分别与利福平、磷霉素联合使用对耐甲氧西林金黄色葡萄球菌(methicillin-resistant staphylococcus aureus,MRSA)防耐药突变浓度的影响,为防止细菌耐药的产生提供理论依据。方法应用肉汤法富集浓度为1010 CFU.ml-1细菌,琼脂平板倍比稀释法测定上述抗菌药物单用及联合使用对10株MRSA临床分离株的防耐药突变浓度,并计算相应的选择指数和耐药频率。结果万古霉素单用对上述10株MRSA的选择指数为16～64;分别与利福平、磷霉素联合使用选择指数下降为2～16和1～8,联合用药较单独用药选择指数下降2～32倍,其耐药频率也大幅下降。结论万古霉素分别与利福平、磷霉素联合使用均可降低其单用对MRSA的防耐药突变浓度,缩小耐药突变选择窗,防止耐药突变菌的产生。
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| 关 键 词： | 耐甲氧西林金黄色葡萄球菌 万古霉素 利福平 磷霉素 联合用药 防耐药突变浓度 耐药突变选择窗 耐药频率 |
Study on mutant prevention concentrations of vancomycin alone and in combination with rifampicin or fosfomycin against MRSA |
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| MEI Qing,YU Ting,ZHU Yu-lin,CHENG Jun,YE Ying,LI Jia-bin. Study on mutant prevention concentrations of vancomycin alone and in combination with rifampicin or fosfomycin against MRSA[J]. Chinese Pharmacological Bulletin, 2011, 27(7): 944-947. DOI: 10.3969/j.issn.1001-1978.2011.07.014 |
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| Authors: | MEI Qing YU Ting ZHU Yu-lin CHENG Jun YE Ying LI Jia-bin |
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| Affiliation: | MEI Qing1,YU Ting1,ZHU Yu-lin1,CHENG Jun1,2,3,YE Ying1,LI Jia-bin1,3 (1.Dept of Infectious Diseases,the First Affiliated Hospital of Anhui Medical University,2.Anhui Center for Surveillance of Bacterial Resistance,3.Institute of Bacterium Resistance,Anhui Medical University,Hefei 230022,China) |
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| Abstract: | Aim To evaluate the mutant prevention concentrations of vancomycin alone and in combination with rifampicin and fosfomycin against Methicillin-resistant staphylococcus aureus(MRSA) in vitro,which provides evidence for new strategies for restricting the development of resistance.Methods The cells of 1010 colony forming units per milliliter coccus were enriched in broth.Mutant prevention concentrations of the above drugs for 10 strains of MRSA were detected with agar dilution method and the value of selective... |
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| Keywords: | methicillin-resistant staphylococcus aureus vancomycin rifampicin fosfomycin combination application of drugs mutant prevention concentrations mutant selection window drug-resistant frequencies. |
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