| 富马酸氯马斯汀注射液在健康人体内药物动力学研究 |
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| 引用本文： | 马忠英,乔逸,彭洁,杨志福,杨林,文爱东.富马酸氯马斯汀注射液在健康人体内药物动力学研究[J].中国药师,2011,14(5):620-624. |
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| 作者姓名： | 马忠英 乔逸 彭洁 杨志福 杨林 文爱东 |
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| 作者单位： | 1. 第四军医大学西京医院药剂科,西安,710033
2. 第四军医大学预防医学系毒理学教研室 |
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| 摘 要： | 目的：研究富马酸氯马斯汀注射液在健康人体内单次和多次给药后药物动力学特征。方法：12名健康受试者单次肌内注射富马酸氯马斯汀注射液2mg；间隔10d后，连续3d肌注富马酸氯马斯汀注射液2mg，bid。给药后LC—MS／MS测定富马酸氯马斯汀血药浓度，DAS2．0药动学软件计算药动学参数。结果：单次和多次给药后主要药动学参数：Cmax分别为（2．43±1．45）、（5．50±0．74）ng·ml^-1；tmax分别为（0．40±0．24）、（0．43±0．26）h；AUC0-12分别为（13．70±6．70）、（49．80±720）ng·h·ml^-1；AUC0-96分别为（65．10±15．70）、（256．90±33．00）ng·h·ml^-1；AUC0-∞分别为（82．50±18．00）、（355．10±116．00）ng·h·ml^-1；t1／2分别为（39．90±7．30）、（46．60±19．10）h。结论：连续3d肌注富马酸氯马斯汀注射液，药物在体内存在蓄积。
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| 关 键 词： | 富马酸氯马斯汀 液质联用色谱法 单 多次给药 药物动力学 蓄积 |
Study on the Pharmacokinetics of Clemastine Fumarate Injection in Healthy Volunteers |
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| Ma Zhongying,Qiao Yi,Peng Jie,Yang Zhifu,Yang Lin,Wen Aidong.Study on the Pharmacokinetics of Clemastine Fumarate Injection in Healthy Volunteers[J].China Pharmacist,2011,14(5):620-624. |
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| Authors: | Ma Zhongying Qiao Yi Peng Jie Yang Zhifu Yang Lin Wen Aidong |
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| Institution: | Ma Zhongying~1,Qiao Yi~1,Peng Jie~2,Yang Zhifu~1,Yang Lin~1,Wen Aidong~1(1.Department of Pharmacy,Xijing Hospital,Fourth Military Medical University,Xi'an 710033 China,2.Department of Toxicology,Faculty of Preventive Medicine,Fourth Military Medical University) |
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| Abstract: | Objective:To study the pharmacokinetics of clemastine fumarate injection after single and multiple-dose intramuscular injection in Chinese healthy volunteers.Method:12 healthy volunteers were administrated 2 mg clemastine fumarate intramuscular injection once a day.After a 10-day washout period,they were administrated 2 mg clemastine fumarate intramuscular injection twice a day for 3 days.The plasma concentrations were determined by LC-MS/MS method.The pharmacokinetic parameters were calculated by DAS 2.0 s... |
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| Keywords: | Clemastine fumarate LC-MS/MS Single-and multiple-dose Phannacokinetics |
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