| 西酞普兰与阿普唑仑治疗广泛性焦虑症的Meta分析 |
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| 引用本文： | 董文燊,林芝,瞿发林,蒋勤.西酞普兰与阿普唑仑治疗广泛性焦虑症的Meta分析[J].中国药师,2011,14(5):688-691. |
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| 作者姓名： | 董文燊 林芝 瞿发林 蒋勤 |
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| 作者单位： | 解放军第102医院,江苏常州,213003 |
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| 摘 要： | 目的：评价西酞普兰与阿普唑仑治疗广泛性焦虑症的疗效及安全性。方法：根据关键词检索出2000～2010年的文献，对入选合格的文献进行Meta分析。结果：共有8篇文献，包括557例患者。在治疗广泛性焦虑症结束后HAMA和SAS评分比较上，西酞普兰明显优于阿普唑仑（P〈0．05），而两者临床显效率和有效率差异无统计学意义。在锥体外系反应和嗜睡的不良反应发生率上，西酞普兰明显低于阿普唑仑（P〈0．05）；在胃肠道反应和口干的不良反应发生率上，阿普唑仑明显低于西酞普兰（P〈0．05）；两者其他不良反应发生率上差异无统计学意义。结论：西酞普兰与阿普唑仑均是治疗广泛性焦虑症的良好药物，不良反应有明显不同，但在中长期治疗中西酞普兰明显优于阿普唑仑。
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| 关 键 词： | 西酞普兰 阿普唑仑 广泛性焦虑症 Meta分析 |
Meta-analysis of Comparative Study on Citaloptam and Alprazolam in the Treatment of Generalized Anxiety Disorder |
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| Dong Wenshen,Lin Zhi,Qu Falin,Jiang Qin.Meta-analysis of Comparative Study on Citaloptam and Alprazolam in the Treatment of Generalized Anxiety Disorder[J].China Pharmacist,2011,14(5):688-691. |
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| Authors: | Dong Wenshen Lin Zhi Qu Falin Jiang Qin |
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| Institution: | Dong Wenshen,Lin Zhi,Qu Falin,Jiang Qin(The 102nd Hospital of PLA,Jiangsu Changzhou 213003,China) |
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| Abstract: | Objective:To assess efficacy and safety of citaloptam and alprazolam in the treatment of generalized anxiety disorder. Method:Retrieved from 2000-2010 literatures based on keywords,qualified ones were evaluated by meta-analysis.Result:Total 8 articles, including 557 patients were analyzed to compare the effect of citaloptam and alprazolam by HAMA and SAS scores at the end of the treatment.The effect of citaloptam was obviously superior to that of alprazolam(P<0.05)while no significant differences were found... |
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| Keywords: | Citaloptam Alprazolam Generalized anxiety disorder Meta-analysis |
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