| 盐酸吡格列酮固体制剂的溶出度考察 |
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| 引用本文： | 刘利群,王爱华,吴雨川,金涛.盐酸吡格列酮固体制剂的溶出度考察[J].中国药师,2011,14(5):675-677. |
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| 作者姓名： | 刘利群 王爱华 吴雨川 金涛 |
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| 作者单位： | 1. 黑龙江省食品药品检验检测所,哈尔滨,150001
2. 黑龙江大学 |
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| 摘 要： | 目的：建立一种对盐酸吡格列酮固体制剂体外溶出情况区别能力更强的溶出度测定方法。方法：通过比较盐酸吡格列酮固体制剂在不同介质中（pH1．0、pH2．0等）的溶出差异性及与参比制剂的体外溶出曲线的相似性采确定溶出方法。结果：采用桨法，以pH2．0缓冲液为溶出介质，转速为50r·min^-1的溶出条件下，国产盐酸吡格列酮固体制剂与参比制剂的溶出行为存在很大差异，而且不同生产厂家的溶出行为具有明显区别。结论：国产制剂的内在质量与参比制剂仍存在较大差异，确定的溶出方法对制剂体外溶出度的区别能力更强。
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| 关 键 词： | 盐酸吡格列酮固体制剂 溶出度 |
Study on Dissolution of Pioglitazone Hydrochloride Solid Preparations |
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| Liu Liqun,Wang Aihua,Wu Yuchuan,Jin Tao.Study on Dissolution of Pioglitazone Hydrochloride Solid Preparations[J].China Pharmacist,2011,14(5):675-677. |
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| Authors: | Liu Liqun Wang Aihua Wu Yuchuan Jin Tao |
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| Institution: | Liu Liqun~1,Wang Aihua~1,Wu Yuchuan~1,Jin Tao~2(1.Heilongjiang Provincial Institute For Food & Drug Control,Harbin 150001,China,2.Heilongjiang University) |
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| Abstract: | Objective:To establish a method for the dissolution determination of pioglitazone hydrochloride solid preparations with more powerful quality discrimination ability.Method:Through studying the variability in the dissolution rates of pioglitazone hydrochloride solid preparations in different medium(pH 1.0 or pH 2.0 buffer solution)and similarity of the dissolution curves between the domestic and imported pioglitazone hydrochloride solid preparations,a reasonable dissolution test was determined.Result:The dif... |
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| Keywords: | Pioglitazone hydrochloride Solid preparations Dissolution rate |
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