儿童毛细血管内增生性肾小球肾炎332例临床与疗效

目的：了解毛细血管内增生性肾小球肾炎（EnPGN）的临床表现与疗效。方法：将1988年6月～2007年11月住院经肾穿刺确诊的EnPGN332例,结合临床表现、疗效进行分析。结果：急性肾炎型290例（87.4%）、单纯性肾病12例（3.6%）、肾炎性肾病27例（8.1%）,无症状性蛋白尿、迁延性肾炎、直立性蛋白尿各1例（0.9%）。临床治愈314例（94.6%）,好转15例（4.5%）,无效3例（0.9%）;其中急性肾炎型治愈275例（94.8%）,好转13例（4.5%）,无效2例（0.7%）;单纯性肾病12例均治愈;肾炎性肾病治愈24例（88.9%）,好转2例（7.4%）,无效1例（3.7%）;无症状性蛋白尿、迁延性肾炎、直立性蛋白尿各1例（0.9%）均治愈。结论：EnPGN以急性肾炎型多见（87.3%）,肾病综合征11.8%,其他0.9%,疗效以急性肾炎型、单纯性肾病型较好,肾炎性肾病型较差。

Clinical and Efficacy Analysis of Endocapillary Proliferative Glomerulonephritis in 332 Children

Objective：To understand the clinical performance and efficacy of endocapillary proliferative glomerulonephritis （EnPGN） in children.Methods：The analysis,which combined with clinical manifestations and efficacy,included all hospitalized cases of EnPGN which diagnosed by renal biopsy between June 1988 and November 2007.Results：There are 290 cases （87.4%） of acute glomerulonephritis 2type,12 cases （3.6%） of simple nephrotic syndrome,and 27 cases （8.1%） of nephritis nephrotic syndrome,1 case （0.9%） of asymptomatic proteinuria,1 case （0.9%） of persistent nephritis and 1 case （0.9%） of orthostatic proteinuria.In all cases,314 cases （94.6%） were clinically cured,15 cases （4.5%） improved and 3 cases （0.9%） failed to respond.In acute glomerulonephritis type,275 cases （94.8%） were cured,13 cases （4.5%） improved and 2 cases （0.7%） failed to respond.All 12 cases of simple nephrotic syndrome were cured.In nephritis nephrotic syndrome,24 cases （88.9%） were cured,2 cases （7.4%）improved and 1 case （3.7%） failed to respond.The cases （0.9%） of asymptomatic proteinuria,persistent nephritis and orthostatic proteinuria were all cured.Conclusion：Acute glomerulonephritis type （87.3%） was the most in EnPGN,followed by nephrotic syndrome （11.8%）,and the least was others （0.9%）.The efficacy of acute glomerulonephritis type and simple nephrotic syndrome were better,and nephritis nephrotic syndrome was worse.