| 内源性大麻素系统对心血管功能的调节作用 |
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| 引用本文： | 周广海,金松南,文今福. 内源性大麻素系统对心血管功能的调节作用[J]. 中国药理学通报, 2011, 27(7): 903-906. DOI: 10.3969/j.issn.1001-1978.2011.07.005 |
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| 作者姓名： | 周广海 金松南 文今福 |
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| 作者单位： | 1. 泰山医学院,动脉粥样硬化研究所,山东,泰安,271000
2. 泰山医学院,药学院药物研究所,山东,泰安,271000 |
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| 基金项目： | 国家自然科学基金资助项目，山东省自然科学基金资助项目 |
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| 摘 要： | 内源性大麻素通过受体依赖性和非依赖性途径经一系列细胞内信号传导通路,可发挥多种重要的心血管效应,如舒张血管、降低血压和抑制心肌收缩等。它还参与抗炎、保护内皮细胞的作用。因此,对其作用机制的深入研究在防治高血压、动脉粥样硬化、缺血/再灌注损伤和心衰等心血管疾病中有重要意义。
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| 关 键 词： | 内源性大麻素 大麻素受体 信号传导 心脏 血管 心血管疾病 |
The endocannabinoid system in regulation of cardiovascular functions |
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| ZHOU Guang-hai,JIN Song-nan,WEN Jin-fu. The endocannabinoid system in regulation of cardiovascular functions[J]. Chinese Pharmacological Bulletin, 2011, 27(7): 903-906. DOI: 10.3969/j.issn.1001-1978.2011.07.005 |
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| Authors: | ZHOU Guang-hai JIN Song-nan WEN Jin-fu |
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| Affiliation: | ZHOU Guang-hai1,JIN Song-nan2,WEN Jin-fu1 (1.Institute of Atherosclerosis,2.Institute of Materia Medica,Taishan Medical University,Taian Shandong 271000,China) |
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| Abstract: | The endocannabinoid exerts various cardiovascular effects such as vasorelaxation,lower blood pressure and negative inotropic effects via multiple signaling transduction by its receptor dependent and independent pathway.It is also involved in anti-inflammatory and endothelial-protecting effects.Therefore,the research on the pharmacological mechanism of the endocannabinoid system(ECS) may play an important role in treatment of hypertension,atherosclerosis,myocardial ischemia reperfusion injury and heart failu... |
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| Keywords: | endocannabinoid cannabinoid receptor signaling pathway heart vascular cardiovascular disease |
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