内阿片肽在电针内关穴对心肌缺血影响中的作用

目的 观察内阿片肽在电针内关穴对心肌缺血影响中的作用。方法 结扎家兔冠脉左室支造成急性心肌缺血模型，以心电图ＳＴ段和心肌缺血范围为指标，随机分对照组、电针内关组和纳洛酮加电针组。结果 电针“内关”能加速急性心肌缺血ＳＴ段的恢复和缩小心肌缺血范围的作用，但被侧脑室微量注射阿片受体拮抗剂纳洛酮阻断。结论 内阿片肽在电针内关减轻急性心肌缺血损伤过程中发挥重要作用，是内关心心脏相关联系的重要因素。

Role of endogenous opiate peptides in the effect of electroacupuncture point Neiguan on acute myocardial ischemia

Objective To investigate the role of endogenous opiate peptides in the effect of electroacupuncture of Neiguan on acute myocardial ischemia. Methods Acute myocardial ischemia (AMI) model was set up by ligating the left ventricular branch of coronary artery of rabbit. ST segment in ECG and scope of AMI were applied as indices to the study. Twenty nine rabbits were randomly divided into 3 groups: control group, electroacupuncture (EA) group and Naloxone with EA group. Results It was found that EA on Neiguan could promote the recovery of ST segment in AMI and decrease the scope of AMI, but this effect was abolished by microinjection of Naloxone (a blocker of opiate receptor) into the lateral ventricle. Conclusion These results suggest that endogenous opiate peptides play an important role in decreasing the damage from AMI by EA on Neiguan and may serve as an important factor in the correlation between point Neiguan and the heart.