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The quinine-haemin interaction and its relationship to antimalarial activity |
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| Authors: | D.C. Warhurst |
| Affiliation: | Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, and Amoebiasis Unit, Hospital for Tropical Diseases, London, U.K. |
| Abstract: | Benzene-soluble complexes of quinine and related antimalarial drugs with haemin (ferriprotoporphyrin IX) were examined spectrophotometrically and gave evidence for coordination of haemin iron with the nitrogen atom of the quinuclidine or piperidine group. The antimalarially inactive 9-epimer of quinine did not show evidence of coordination with haemin. A model of the interaction is presented. |
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