MHC class I chain-related gene A transmembrane polymorphism in Spanish women with breast cancer |
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Authors: | R. Lavado-Valenzuela,M. Benavides,F. Carabantes,A. Alonso,& A. Caballero |
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Affiliation: | Immunology Service, Carlos Haya Regional University Hospital, Malaga, Spain; Medical Oncology Section, Carlos Haya Regional University Hospital, Malaga, Spain |
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Abstract: | The NKG2D–major histocompatibility complex class I-related chain A (MICA) system plays a key role in the antitumoral immune response. We studied five alleles of a microsatellite in the MICA transmembrane region; one of which ( MICA-A5.1 ) gives rise to a truncated protein. The MICA-A5 allele was reduced in breast cancer patients compared with healthy controls ( P = 0.04). Given the association between the HLA-B7 allele and the susceptibility to breast cancer in our area, we also analyzed the distribution of the frequency of the MICA alleles in human leukocyte antigen (HLA)-B7 patients compared with patients with the other alleles. The MICA-A5.1 allele was increased in HLA-B7 patients ( P = 0.0003). These results suggest that the MICA-A5 allele appears to confer protection against human breast cancer and that the MICA-A5.1 appears to increase the susceptibility to breast cancer in HLA-B7 patients in our area. |
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Keywords: | breast cancer HLA-B7 MICA polymorphisms susceptibility and protection |
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