| 复方愈创木酚甘油醚双层缓释片释放度及释药机制研究 |
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| 引用本文： | 陈俊 平其能. 复方愈创木酚甘油醚双层缓释片释放度及释药机制研究[J]. 中国药学杂志, 1999, 34(12): 815-817 |
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| 作者姓名： | 陈俊 平其能 |
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| 作者单位： | 中国药科大学药剂教研室 南京 210009;1本校98届本科毕业生 |
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| 摘 要： | 目的:比较双层缓释片与Sidmak缓释片的释放度,并进行动力学分析?方法:建立复方愈创木酚甘油醚双层缓释片溶出度实验方法,用紫外法和比色法分别测定该制剂中愈创木酚甘油醚(GF)及盐酸苯丙醇胺(PPA)的释放度?结果:双层缓释片起始释药量减低,在4～8h释药量明显增加,呈现2次释药;对照缓释片在整个释药过程符合一级动力学?结论:双层片药物滞后释放,增加了缓释特性,特别适合水溶性大半衰期短的药物缓释制剂的制备?
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| 关 键 词： | 双层缓释片 愈创木酚甘油醚 盐酸苯丙醇胺 |
| 收稿时间： | 1998-08-10; |
Evaluation of double layer tablets release and its kinetics of compound guaifenesin and phenylpropanolamine hydrochloride |
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| Chen Jun. Evaluation of double layer tablets release and its kinetics of compound guaifenesin and phenylpropanolamine hydrochloride[J]. Chinese Pharmaceutical Journal, 1999, 34(12): 815-817 |
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| Authors: | Chen Jun |
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| Affiliation: | (Chen J)，Ping Qineng(Ping QN)，Liu Guojie(Liu GJ)，et a |
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| Abstract: | OBJECTIVE: The release behaviors and kinetics of two complex tablets were compared.The one was a double layer tablet; another was a homogeneous matrix tablet.METHOD: A Spectrophotometric method was developed to determine guaifenesin (GF) and phenylpropanolamine hydrochloride (PPA) in the release process of two sustained release tablets.RESULTS: The double layer tablet showed biphasic release.The amount of release at beginning was low, and then increased in the period of 4～8 hour obviously.CONCLUSION: The release behavior of the double layer tablet improved the property of sustained release, which is especially suitable to the soluble and shorter t1/2 drugs. |
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| Keywords: | double layer sustained release tablet guaifenesin phenylpropanolamine hydrochloride spectrophotometric method |
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