GENETIC POLYMORPHISMS OF ALCOHOL METABOLIZING ENZYMES RELATED TO ALCOHOL SENSITIVITY AND ALCOHOLIC DISEASES |
| |
Authors: | YOSHIDA AKIRA |
| |
Affiliation: | Department of Biochemical Genetics, Beckman Research Institute of the City of Hope 1450 E. Duarte Road CA 9l010, U.S.A. |
| |
Abstract: | Indiciduals with the atypical aldehyde dehydrogenase ALDH22allele, both homozygous and heterozygous status, are alcoholsensitive and have a markedly reduced risk of developing alcoholicdiseases. Genetic abnormalities of the ALDH1 locus are alsoassociated with alcohol flushing. The ALDH3 and ALDHx, lociare polymorphic and their variations may affect the developmentof alcoholic diseases. The variations of alcohol dehydrogenaseADH2 and ADH3 loci have no profound effects on alcohol sensitivity.The newly identified ADH6 gene has hormone response elements,and it may cause the gender difference in alcoholic problems. |
| |
Keywords: | |
本文献已被 Oxford 等数据库收录! |
|