Neonatal allo-immune thrombocytopenia due to fetomaternal HPA-1 incompatibility of a homozygous HPA-1a mother and a homozygous HPA-1b father |
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| Authors: | R Moser I Fae A Neumeister M Pober I Mutz S Panzer |
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| Institution: | (1) Department of Paediatrics, Krankenhaus Loeben, A-8700 Loeben, Austria;(2) Institute for Blood Group Serology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria |
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| Abstract: | We report a case of neonatal allo-immune thrombocytopenia due to fetomaternal human platelet antigen (HPA)-1 incompatibility. Anit-HPA-1b antibodies were detectable in maternal serum. Repeated treatment of the infant with high-dose IgG effectively raised platelet counts transiently, but the patient remained thrombocytopenic for more than 6 weeks. Serological and DNA analysis revealed that the mother was homozygous HPA-1a and the father homozygous HPA-1b |
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| Keywords: | Neonatal allo-immune thrombocytopenia HPA-1b HLA class-I and class-II molecules |
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