| 丙泊酚对大鼠冷缺血心肌的保护效应 |
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| 引用本文： | 周春燕,陈玉培. 丙泊酚对大鼠冷缺血心肌的保护效应[J]. 重庆医学, 2008, 37(22): 2575-2577 |
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| 作者姓名： | 周春燕 陈玉培 |
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| 作者单位： | 重庆市第三人民医院麻醉科,400014;重庆医科大学附属第二医院麻醉科,400010 |
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| 摘 要： | 目的 观察丙泊酚不同处理方式对离体大鼠缺血再灌注心肌的保护效应,探索其最佳给药途径.方法 对大鼠离体心脏行改良Langendorff灌流,将32只SD大鼠随机分为4组,每组8只.A组持续正常K-H液灌注40min后全心停灌30min,再灌注60min;B组平衡20min后用含50/μmol/L丙泊酚K-H波灌注10min,再用K-H液冲洗10min,缺血与再灌注处理同A组;C组K-H液灌注40min,全心停灌30min后再灌注时先用含50μmol/L丙泊酚K-H液灌注10min,再用K-H液灌注50min;D组平衡20min后用含50μmol/L丙泊酚K-H液灌注20min,全心停灌30min,再用含50μmol/L丙泊酚K-H液灌注60min.观察缺血再灌注期间HR,LVDP、LVEDP、±dp/dtmax变化及灌注末心肌组织中丙二醛(MDA)含量、心肌超氧化物歧化酶(SOD)活性.结果 再灌注后,与A组相比,B、C、D组HR、LVDP、LVEDP、±dp/dtmax均有显著变化(P<0.01),D组各项血流动力学指标均优于B、C组(P<0.05).与A组相比,B、C、D组SOD活性均明显增高,MDA含量减少,差异有统计学意义(P<0.01),以D组更为显著.结论 丙泊酚对离体大鼠缺血再灌注心肌有保护效应,缺血前后持续以含50μmol/L丙泊酚K-H液灌注保护效应最为明显.
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| 关 键 词： | 丙泊酚 再灌注损伤 心肌 |
Protective effects of propofol on isolated rat heart against ischemia reperfusion injury |
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| ZHOU Chun-yan,CHEN Yu-pei. Protective effects of propofol on isolated rat heart against ischemia reperfusion injury[J]. Chongqing Medical Journal, 2008, 37(22): 2575-2577 |
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| Authors: | ZHOU Chun-yan CHEN Yu-pei |
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| Affiliation: | ZHOU Chun-yan1,CHEN Yu-pei2(1.Department of Anesthesiology,the Third People's Hospital of Chongqing City,Chongqing 400014,China,2.Department of Anesthesiology,the Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China) |
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| Abstract: | Objective To investigate the protective effects of different treatment modus of propofol on isolated rat hearts against ischemia-reperfusion injury,and to explore the optimal administration route.Methods 32 SD rat hearts were isolated and perfused with oxygenated Krebs-Hensleit(K-H)solution in a Langendorff apparatus.The isolated hearts were randomly divided into 4 groups(8 hearts each group):ischemia-reperfusion group(A group)in which the isolated hearts were subjected to 30 min no-flow global ischemia fol... |
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| Keywords: | propofol reperfusion injury myocardium |
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