马来酸桂哌齐特相关腹泻

1例50岁男性患者,因心绞痛入院。给予阿魏酸钠0.3g入0.9%氯化钠注射液150ml静脉滴注,1次/d;马来酸桂哌齐特160mg入5%葡萄糖注射液250ml静脉滴注。同时口服阿司匹林、阿托伐他汀、贝那普利、单硝酸异山梨酯。入院当日静脉滴注完毕后患者出现腹泻10余次,水样便。次日再次静脉滴注后症状加重。考虑腹泻可能与马来酸桂哌齐特有关,遂停用该药,其余药物继续使用,患者腹泻停止。

Diarrhea ralated to cinepazide maleate

A 50-year-old man was hospitalized for angina pectoris.He received an IV infusion of sodium ferulate 0.3 g dissolved in 0.9% sodium chloride 150 ml and an IV infusion of cinepazide maleate 160 mg in 250 ml of glucose 5%.Meanwhile he was given aspirin,atorvastatin,benazepril,and isosorbide mononitrate.On admission,the patient developed diarrhea with 10 watery stools per day after infusion completion.On second day,his symptoms aggravated after readministration of an intravenous infusion.His diarrhea was considered possibly related to cinepazide maleate,and then cinepazide maleate was withdrawn and other medications were continued,his diarrhea stopped.