帕金森病合并抑郁状态的发生率及相关因素分析

目的了解帕金森病合并抑郁状态的发生率,并对其相关因素进行探讨。方法对2000-03~2001-03北京天坛医院神经内科门诊就诊的127例原发帕金森病人采用抑郁自评量表、汉密顿抑郁量表、统一帕金森病评分量表及自制一般情况调查表进行测查,得到本组病人的帕金森病伴发抑郁状态发生率,通过显著性检验及Logestic回归等统计方法对各因素进行相关分析。结果帕金森病伴发抑郁状态观察组发生率为47.2%(60/127),其中轻度抑郁14.2%,中度抑郁28.3%,重度抑郁4.7%。PDD发生的相关因素按标准回归系数依次为性别、疾病严重程度、运动障碍严重程度、文化程度、是否应用多巴受体激动剂5项。结论帕金森病合并抑郁状态是多种因素共同作用所致,上述相关因素的检查可以预测帕金森病合并抑郁状态的出现,并为其防治提供多个位点。

Incidence and related factors of depression in Parkinson disease

Objective To survey the incidence of depression in Parkinson disease(PDD) and explore the related factors of PDD.Methods 127 patients with Parkinson disease were investigated,all of them were assessed by Hamilton Depression Rating Scale,self-designed register form and the Unified Parkinson disease scale(UPDRS).A stepwise multiple factor regression analysis was carried out to determine factors that best accounted for the occurrence of PDD.Results The overall incidence rate was 47.2%.The minor,moderate and major incidence was 14.2%,28.3% and 4.7% respectively.The regression analysis showed that factors accounted for the occurrence of PDD were gender,the severity of PD,stage of patient's motor impairment,education level and the use of dopamine agonists.Conclusion PDD seems to have a multifactorial etiology.Knowledge of risk factors related to the occurrence of PDD may help guide neurologists in the early prediction and treatment of this disease.