Effects of the benzazepine SCH 23390 on prolactin release from isolated pituitary |
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Authors: | P Navarra R del Carmine E Ragazzoni M Vacca P Preziosi |
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Affiliation: | Department of Pharmacology, Catholic University of the Sacred Heart, Roma, Italy. |
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Abstract: | The benzazepine, SCH 23390 (10(-5) M), is able to block D2 anterior pituitary receptors and their interaction with a maximal concentration of dopamine (10(-7) M) in an experimental setting involving superfused pituitary slices and prolactin release by lactotrophs as a functional model of such receptors; this finding which correlates nicely with binding studies and drug-induced hyperprolactinaemia supports a SCH 23390 D1 dose-related selectivity; given at doses higher than those inducing behavioural changes, the compound may affect D2 receptor-driven functions, e.g. prolactin secretion. |
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