低浓度一氧化碳对小鼠神经行为功能的影响

目的研究氏浓度一氧化碳（ＣＯ）的神经行为毒理学效应及限时最大容许浓度（ＭＡＣ）。方法４０只昆明小鼠随机等分为４组：Ａ组（对照组，吸入空气），Ｂ组（吸入３０ｍｇ／ｍ＾３ＣＯ），Ｃ组（吸篱３００ｍｇ／ｍ＾３ＣＯ），Ｄ组（吸入６００ｍｇ／ｍ＾３ＣＯ）。各组分地０．５ｍ＾３容积的静式染毒柜中，持续染毒７２ｈ。在染毒前中、后，测试小鼠在水迷宫的反应时和错误率及在开阔场的走格子数和排便次数。结果 染毒期间Ｄ组

Effects of low Concentration Carbon Monoxide on the Neurobehavior Function in Mice

Objective To study the effect of low concentration CO on neurobehaviour function and the maximal allowable concentration(MAC) in limited time. Method 40 KM (kunming) male mice were randomly divided into groups A,B,C and D. They were exposed to normal air, 30 mg/m 3 CO, 300 mg/m 3 CO and 600 mg/m 3 CO respectively. The changes in neurobehaviour function of the mice before,during and after 72 h exposure in 0.5 m 3 static chambers were observed. Four indices were measured: response time (RT) and error rate (ER) in the water maze test, enter check frequency (ECF) and urine or excrement frequency (UEF) in open field test. Result The set upright frequency in group D was smaller than those in groups A,B and C during exposure. RT and ER values went in a direction contrary to pre exposure the four groups in the second 3 days (6 d) after or out of exposure, while ER values showed that group D>group C>group A>group B in the third 3 days (9 d).RT value was not different among the 4 groups, but its order of numerical value was similar to the ER order. The order of ECF values was that group C>group A and group D in 3 d after or out of exposure and not different among the 4 groups in 6 d and group Dgroup A and group B in 6 d after or out of exposure. Comparison with every group itself, showed statistically significance increase in ER values in 9 d out of exposure than before exposure in group D. ECF values showed the statistics significant increase in 9 d in group A and B. Conclusion Low concentration CO may interfere with the learning and memory of mice in the water maze and impede the development of the motor nervous function and disturb the steadiness of emotion of mice in the open field. In addition, low concentration of CO may be of tardy toxicity.