Transient neonatal diabetes and later onset diabetes: a case of inherited insulin resistance. |
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| Authors: | J P Shield J D Baum |
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| Affiliation: | Institute of Child Health, Bristol. |
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| Abstract: | A 13 year old girl who had had transient neonatal diabetes developed permanent diabetes. She had raised fasting insulin concentrations suggestive of insulin resistance with a suboptimal insulin response to glucose loading. Both her mother and sister had profound insulin resistance; neither had clinical diabetes. This is the first time inherited insulin resistance has been implicated in the pathogenesis of permanent diabetes developing after transient neonatal diabetes. |
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