The relationship between serum apelin levels and aortic dilatation in bicuspid aortic valve patients |
| |
Authors: | Ersin agr imek Selcen Yakar Tülüce Kamil Tülüce Sadk Volkan Emren Serap uhadar Cem Nazl |
| |
Institution: | 1.Department of Cardiology, University
of Health Science, Tepecik Training and
Research Hospital, Izmir, Turkey
2 Department of Cardiology, Katip Çelebi
University Atatürk Training and Research
Hospital, Izmir, Turkey
3 Department of Cardiology, Çi?li Regional
Training Hospital, Izmir, Turkey
4 Department of Biochemistry, Katip Çelebi
University Atatürk Training and Research
Hospital, Izmir, Turkey |
| |
Abstract: | Objective: The bicuspid aortic valve (BAV) is the most common congenital heart dis‐
ease. The process of aortic dilatation is not completely clear in patients with the BAV.
Apelin is a peptide found at high levels in vascular endothelial cells which has a role
in vascular regulation and cardiovascular function. The aim of this study was to de‐
termine the relationship between serum apelin levels and ascending aortic dilatation
in adult patients with BAV.
Design: This cross‐sectional study included 62 patients with isolated BAV and to an
age, gender, and body mass index‐matched control group of 58 healthy volunteers
with tricuspid aortic valve. Transesophageal echocardiography was performed on all
patients to determine the type of BAV. Aortic diameters of the aortic root, sinus val‐
salva, sinotubular junction, and ascending aorta were evaluated with echocardiogra‐
phy. Patients with BAV were divided into two subgroups according to the aortic
diameters, as the nondilated BAV group and the dilated BAV group. Serum apelin
level was analyzed with ELISA method.
Results: The serum apelin levels of the BAV patients were significantly lower than
those of the control group (833.5, 25th‐75th percentile (713.5‐1745) pg/dL vs 1669
(936‐2543) pg/dL; P = 0.006). In the subgroup analysis, serum apelin level was signifi‐
cantly different between the nondilated BAV group and the dilated BAV group 977
(790‐2433) pg/dL vs 737 (693‐870) pg/dL, P < 0.05] and between the dilated BAV
group and the control group 737 (693‐870) pg/dL vs 1669 (936‐2543) pg/dL,
P < 0.001]. In multivariate logistic regression analysis apelin 7.27 (95% CI: 1.73‐30.42),
P = 0.007] and age 1.05 (95% CI: 0.99‐1.20), P = 0.049] were determined as inde‐
pendent predictors for ascending aortic dilatation.
Conclusion: Low serum apelin level was associated with dilatation of ascending aor‐
tic in BAV patients. However, apelin was not relevant to BAV without aortic
dilatation. |
| |
Keywords: | aortic aneurysm aortic dilatation apelin bicuspid aortic valve |
|
| 点击此处可从《》浏览原始摘要信息 |
| 点击此处可从《》下载免费的PDF全文 |
|