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Natural compounds with xanthine oxidase inhibitory activity: A review
Authors:Arshad Mehmood  Muhammad Ishaq  Lei Zhao  Bushra Safdar  Ashfaq‐ur Rehman  Masooma Munir  Ali Raza  Muhammad Nadeem  Waheed Iqbal  Chengtao Wang
Abstract:Hyperuricemia (HUA), a disease due to an elevation of body uric acid level and responsible for various diseases such as gout, cardiovascular disorders, and renal failure, is a major ground debate for the medical science these days. Considering the risk factors linked with allopathic drugs for the treatment of this disease, the debate has now become a special issue. Previously, we critically discussed the role of dietary polyphenols in the treatment of HUA. Besides dietary food plants, many researchers figure out the tremendous effects of medicinal plants‐derived phytochemicals against HUA. Keeping in mind all these aspects, we reviewed all possible managerial studies related to HUA through medicinal plants (isolated compounds). In the current review article, we comprehensively discussed various bioactive compounds, chemical structures, and structure–activity relationship with responsible key enzyme xanthine oxidase.
Keywords:bioactive compounds  hyperuricemia  medicinal plants  uric acid  xanthine oxidase inhibitory activity
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