中医药治疗非甾体消炎药相关性胃肠损伤的研究进展

非甾体消炎药(non-steroid anti-inflammatory drugs,NSAIDs)临床应用广泛,是全世界范围内处方量最大的药物之一。长期服用NSAIDs 可出现相关胃肠道损伤,主要表现为黏膜糜烂、溃疡、出血、穿孔,可直接致死,严重危害人民健康。当前防治方法十分有限,主要以质子泵抑制剂、黏膜保护剂、微生态制剂以及对症治疗为主,疗效欠佳。中医中药以辨证施治为基础,在预防和治疗NSAIDs相关性胃肠损伤中疗效明显,不良反应较少。本文对近年来中医药治疗非甾体消炎药相关性胃肠损伤的相关基础及临床研究作一综述,明确中医药在非甾体消炎药相关性胃肠损伤防治中的理论依据及优势。

Research Progress of Traditional Chinese medicine in the Treatment of Non-steroidal Anti-inflammatory Drugs Related Gastrointestinal Injury

Non-steroidal anti-inflammatory drugs (non-steroid anti-inflammatory drugs, NSAIDs) are widely used, which is one of the world"s most prescribed drugs nowadays. Long-term use of NSAIDs will cause gastrointestinal injury, mainly manifested as mucosal erosion, ulcer, bleeding and perforation, which can directly cause death, which seriously endanger people"s health. Currently, the prevention and treatment methods are very limited, mainly including proton pump inhibitors, mucosal protective agents, microecological agents and symptomatic treatment, with poor efficacy. Traditional Chinese medicine (TCM), based on syndrome differentiation and treatment, is effective in preventing and treating NSAIDs related gastrointestinal injury with fewer adverse reactions. This paper summarizes the basic and clinical research of TCM in the treatment of NSAIDs related gastrointestinal injury in recent years, and clarifies the theoretical basis and advantages of TCM in the prevention and treatment of NSAIDs related gastrointestinal injury.