Coronary artery disease in adults with tetralogy of Fallot

Background: There are limited data about outcomes of coronary artery disease(CAD) in adults with repaired tetralogy of Fallot (TOF). The purpose of this study wasto describe the prevalence and treatment of CAD in adults with TOF, and the impactof CAD on long‐term survival.
Methods: Retrospective review of MACHD database for adults with repaired TOFwho underwent aortic root/selective coronary angiogram, 1990‐2017. Patients werecategorized into three groups: (1) No CAD defined as normal coronary angiogram; (2)Mild CAD defined as ≤50% stenosis in all vessels; and, (3) Significant CAD definedas >50% stenosis in any vessel.
Results: We identified 105 (23%) of 465 TOF patients that had angiograms; meanage 47 ± 12 years. The prevalence of mild CAD and significant CAD was 19% (20 pa‐tients) and 15% (16 patients), respectively. Of these 16 patient with significant CAD,9 (56%), 3 (19%), and 4 (24%) patients received guideline directed medical therapy,percutaneous coronary intervention, and coronary artery bypass grafting, respec‐tively. Significant CAD was an independent risk factor for mortality (HR: 2.03, 95% CI1.64‐4.22, P = .022) after adjustment for differences in age, and prevalence of atrialfibrillation and renal dysfunction.
Conclusions: Based on a review of a selected cohort of 105 TOF patients, the preva‐lence of mild CAD and significant CAD was 19% and 15%, respectively. SignificantCAD was an independent risk factor for mortality. There is need for more researchto determine optimal noninvasive diagnostic strategies and optimal patient selectionsand methods for revascularization.