Design,synthesis, and biological activity evaluation of campthothecin‐HAA‐Norcantharidin conjugates as antitumor agents in vitro |
| |
| Authors: | Xian H. Wang Mei Huang Chang K. Zhao Chan Li Lang Xu |
| |
| Abstract: | Three components of Camptothecin, hydroxyacetic acid, and functionalized norcantharidins were constructed together to form a novel series of camptothecin derivatives in a good yield. The synthesized campthothecin‐HAA‐norcantharidin conjugate pro‐drugs could suppress cancer cell growth in vitro. These conjugated pro‐drug molecules possess therapeutic potential as novel bi‐functional conjugates platforms for cancer treatment. |
| |
| Keywords: | camptothecin conjugate hydroxyacetic acid norcantharidin pro‐drug |
|
|
