短小棒状杆菌菌苗对反复呼吸道感染的防治及其免疫学观察

反复呼吸道感染是哮喘与慢性支气管炎患者的常见发作原因。本文试用短小棒状杆菌(CP)菌苗对25例此类患者进行前瞻性的防治与免疫学观察。患者每日记录病情与用药量,治疗3月后72％患者获效,52％显效。治前曾作淋转试验(~3H-TdR 法)者19例,其中11例低于正常,治疗后 8例恢复正常,2例有所上升。体内实验方面,约 1/5患者在治疗后皮肤 OT与 SK-SD试验有所增强,但PHA皮试变化不多。作者等初步认为CP主要通过提高巨噬细胞和T细胞功能而发挥上述作用的。

CORYNEBACTERIUM PARVUM IN THE TREATMENT OF RECURRENT RESPIRATORY INFECTION AND ITS IMMUNOLOGIC INVESTIGATION

Twenty-five cases of asthma and chronic bronchitis complicated with recurrent respiratory infection were treated with Corynebacterium parvum (CP) vaccine. The results were investigated by daily symptoms and drug-consumption records and some of the im-munologic examinations.After three-months therapy 12% of the patients had their symptoms improved and 52% markedly improved. 11 out of 19 cases had a decreased 3H-TdK value(lymphoblastoid transformation test) and recovered in 8 cases after CP treatment (P<0.001). As to the in vivo test, following treatment OT and SK-SD skin test respectively were intensified in 21.7% and 34.8% but weakened in 4.3% and 13.1% of the cases tested (P<0.005). It is thought that the clinical effect of CP may be correlated with the enhanced function of macrophage and T-lymphocyte.