米氮平治疗功能性消化不良疗效评价

目的 已有使用抗抑郁药治疗功能性消化不良(FD)合并心理障碍的报道,本研究总结评价去甲肾上腺素和5-羟色胺再摄取抑制剂米氮平治疗FD的疗效及安全性.方法 收集北京协和医院消化内科2009年6月～2010年6月接受米氮平治疗的FD患者资料,随诊内容包括消化不良症状、食欲和体重、精神心理状态和睡眠情况等.总结分析米氮平的疗...

Retrospective Evaluation for the Efficacy of Mirtazapine on Functional Dyspepsia

Objective Antidepressants are prescribed for patients with functional dyspepsia（FD） while they are failed to regular medications. There was less experience about noradrenaline and serotonin re-uptake inhibitor-mirtazapine on FD patients with psychological disorders. The aim of this study is to evaluate the efficacy and safety of mirtazapine in treatment for FD patients.Methods The retrospective data were colected for the patients with FD who were treated with mirtazapine and followed-up at least two weeks in clinic of Peking union medical college hospital from June 2009 to June 2010.The patient＇ s dyspeptic symptoms,treatment,psychological status were analyzed. Results A total of 50 FD patients（11 male and 39 female） met RomeⅢcriteria were enrolled.Mean age was 46.6±12.7 years.Mirtazapine at the beginning dose is at 10 mg for most cases,and maintenance dose is 15 mg for 46%,and 30 mg for 22%cases.The course of treatment was 2 weeks to 12 months.Of 46 patients reported their global symptoms improved after mirtazapine treatment,dyspeptic symptoms were at the first list improved symptoms in 31 patients.Body weight increased for 24 patients,and sleep improved for 28 patients,and co-exist psychological disorders also improved in some cases.The adverse effects associated with mirtazapine occur in 5 cases（fatigue,nausea and leukocytes decrease）.Conclusion The retrospective data show mirtazapine is effctive on improve integrative symptoms with FD patients and the adverse effect is fewer.