甘氨双唑钠对局部晚期非小细胞肺癌放疗的增敏作用

目的:观察甘氨双唑钠(CMNa)配合放疗对局部晚期非小细胞肺癌(NSCLC)的疗效和毒副反应。方法:65例Ⅲ期NSCLC患者随机分为二组:治疗组(放疗 CMNa)35例,放疗采用常规分割,原发灶及纵隔淋巴结剂量DT60Gy～66Gy/30f～33f/6w～7w。放疗同时使用CMNa每次800mg/m2,每周3次,从放疗开始连续使用至放疗结束;对照组30例只行放射治疗,剂量、分割方式同治疗组。治疗完成后评价疗效和不良反应。结果:治疗组总有效率(CR PR)74.3%,完全缓解率(CR)22.9%;对照组总有效率50.0%,完全缓解率10.0%,两组间总有效率有显著统计学差异(P=0.043)。中位生存期治疗组和对照组分别为13个月和11个月,1、2年生存率治疗组分别为60.0%、31.4%;对照组分别为50.0%、23.3%,两组间统计学差异无显著性(P>0.05)。毒副反应主要是放射性肺炎、放射性食管炎和骨髓抑制,两组间差异无显著性。结论:CMNa合并放疗可明显提高局部晚期非小细胞肺癌(NSCLC)的近期疗效,远期疗效略有提高,但无统计学差异。

Clinical study of radiosensitivity on non -small cell lung cancer by CMNa

Objective:To observe the effects and toxic effects of radiosensilizer melronidazole amino acidum(CMNa)for non-small cell lung carcinoma(NSCLC).Methods:Sixty five patients were enrolled into two groups:35 cases in the treatment group received concurrent chemotherapy(CMNa 800mg/m2/time,thrice/week),radiotherapy :the total tumor dose was DT 60Gy~66 Gy/30~33f/6~7w.30 cases in the control group received radiotherapy alone.The method of radiotherapy in control group was as same as that in treatment group.Results:The overall response rate(CR PR)in the treatment group was 74.3% with a complete response rate(CR)22.9%.The overall response rate(CR PR)in the control group was 50.0% with a complete response rate(CR)10.0%.The difference of overall response rate between two groups was statistically significant(P<0.05).The median survival time,1,2-year survival rates were 13 months,60.0%,31.4% for the treatment group,and 11 months,50.0%,23.3% for the control group(P>0.05)respectively.The incidence of radiation pneumonitis and esophagitis was not different(P>0.05)between the treatment group and control group.Conclusion:CMNa is radiosentizative to non-small cell lung cancer.It could increase immediate response of NSCLC without severe toxicities.