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Increased Hyaline Droplet Formation in Male Rats Exposed to Decalin Is Dependent on the Presence of {alpha}2u-Globulin
Authors:RIDDER, GREGG M.   BARGEN, EDWARD C. VON   ALDEN, CARL L.   PARKER, RONALD D.
Affiliation:The Procter & Gamble Company, Miami Valley Laboratories Cincinnati, Ohio 45239–8707

Received February 27, 1990; accepted July 6, 1990

Abstract:Increased Hyaline Droplet Formation in Male Rats Exposed toDecalin Is Dependent on the Presence of {alpha}2u-Globulin. RIDDER,G. M., VON BARGEN, E. C., ALDEN, C. L., AND PARKER, R. D. (1990).Fundam. Appl. Toxicol. 15, 732–743. A peculiar decalin-inducedmale rat nephropathy associated with the altered renal handlingof filtered protein appears limited to the accumulation of theprotein, {alpha}2u-globulin. Several strains of male rats that produce{alpha}2u-globulin (Fischer-344, Sprague-Dawley, Buffalo, and NorwayBrown) demonstrate spontaneous renal cortical hyaline dropletswhich are exacerbated after exposure to decalin. In all cases,a close correlation exists between hyaline droplet formationobserved histologically and {alpha}2u-globulin accumulation measuredbiochemically. In stark contrast, the NCI-Black-Reiter strain,which does not produce measurable quantities of {alpha}2u-globulin,neither forms hyaline droplets nor accumulates any filteredprotein in its kidney cortex either spontaneously or after exposureto decalin. Also, female rats injected ip with male rat {alpha}2u-globulinexhibit increased hyaline droplet formation and {alpha}2u-globulinaccumulation when treated with decalin. These data provide evidencethat the presence of {alpha}2u-globulin is key in understanding whythis nephropathy appears unique to the male rat.
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