An ontogenic study of histamine and mast cells in the fetal rhesus monkey |
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Authors: | Lester W. Schwartz Bennie I. Osburn Oscar L. Frick |
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Affiliation: | 1. From the California Primate Research Center and Department of Pathology, School of Veterinary Medicine, University of California, Davis, Calif., USA;2. From Department of Pediatrics, University of California, San Francisco, Calif., USA |
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Abstract: | This study was designed to determine the presence of cell-bound histamine and mast cells, if any, in the lung and skin of nonhuman primate fetuses and neonates. The results indicate that cell-bound histamine can be detected in both tissues of the rhesus monkey fetus by 60 days of gestation, the earliest age examined, at levels that are 2% to 3% of levels present in yearling animals. Levels increase markedly during the last life mo of gestation; however, at birth, levels are only 12% to 46% of those observed in the yearling and are lower than levels observed at 150 days of gestation. Mast cell numbers in lung and skin of the fetus closely parallel histamine content. |
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Keywords: | Reprint requests to: Dr. L. W. Schwartz California Primate Research Center University of California Davis Calif. 95616. |
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