Flavonoids from the aerial parts of <Emphasis Type="Italic">Houttuynia cordata</Emphasis> attenuate lung inflammation in mice |
| |
Authors: | Ju Hee Lee Jongmin Ahn Jin Woong Kim Sang Gook Lee Hyun Pyo Kim |
| |
Institution: | 1.College of Pharmacy,Kangwon National University,Chuncheon,Korea;2.College of Pharmacy,Seoul National University,Seoul,Korea |
| |
Abstract: | The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess anti-inflammatory activity, especially in the lung, the pharmacological activities of H. cordata and the flavonoid constituents were evaluated using in vitro and in vivo models of lung inflammation. The 70 % ethanol extract of the aerial parts of H. cordata inhibited the production of inflammatory biomarkers IL-6 and NO in lung epithelial cells (A549) and alveolar macrophages (MH-S), respectively. And the same plant material, administered orally (100 and 400 mg/kg), significantly inhibited lung inflammatory response in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury. From the extract, major flavonoids including afzelin, hyperoside and quercitrin were successfully isolated and they also attenuated LPS-induced lung inflammation in mice by oral administration. In particular, quercitrin showed most potent activity at 100 mg/kg. These results demonstrate for the first time that H. cordata and three flavonoid constituents have a therapeutic potential for treating lung inflammatory disorders. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|