| Abstract: | The effect of neurohormone C, a new coronary dilator isolated from bovine hypothalamus, on activity of the phosphodiesterase (PDE) of cyclic adenosine-3 ,5-monophosphate (AMP) was investigated. Considerable inhibition of PDE was shown in the supernatant of rat brain and heart homogenates (2000g) under the influence of neurohormone C. The existence of correlation between the coronary dilator effect of the hormone and regulation of the cyclic AMP level under the influence of a change in PDE activity is postulated.Laboratory of Hormones, Institute of Biochemistry, Academy of Sciences of the Armenian SSR, Erevan. (Presented by Academician of the Academy of Medical Sciences of the USSR S. E. Severin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 6, pp. 691–693, June, 1977. |
