The effect of sulphinpyrazone and alpha-tocopherol on platelet activation and function in haemodialysed patients |
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| Authors: | A. Dmoszyńska-Giannopoulou L. Janicka B. Sokołowska A. Ksi⇂żek G. Orłowska K. Janicki |
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| Affiliation: | (1) Department of Haematology and Nephrology, Medical School, Lublin, Poland |
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| Abstract: | In 30 patients on chronic haemodialysis treatment the platelet activity and function were studied before and during antiplatelet therapy with alpha-tocopherol and sulphinpyrazone. In both kinds of treatment a significant decrease of ADP-induced and spontaneous aggregation was observed. Sulphinpyrazone exerts an inhibitory effect not only on platelet aggregation but also on platelet factor 3 and provokes a significant prolongation of the bleeding time. |
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