人乳头瘤病毒及血清SCCA和CA-199检测在宫颈癌及癌前病变中的意义

目的探讨宫颈上皮内瘤变(CIN)和宫颈癌中鳞状细胞癌抗原(SCCA)、糖链抗原(CA-199)的表达及HPV16/18感染情况在宫颈癌及癌前病变中的意义。方法检测150例CIN和100例宫颈癌患者HPV、SCCA和CA-199表达情况,观察各指标与宫颈癌的不同病理类型、临床分期、组织分化、肿块类型和淋巴结转移的关系。结果随着CIN分级的升高,HPV、血清SCCA和CA-199的表达逐渐增强,并且宫颈癌患者的HPV、血清SCCA和CA-199表达显著高于CIN患者。HPV表达与患者的病理类型、临床分期、组织分化、肿块类型和淋巴结转移无关。血清SCCA和CA-199表达与临床分期、组织分化和淋巴结转移存在明显的相关性,而与肿块类型无关,两者不同的是SCCA的血清表达与病理类型有关,而CA-199与病理类型无关。结论综合分析宫颈癌患者的血清SCCA和CA-199及HPV阳性率能为患者的辅助诊断、病情估计提供全面的指导信息。

Significance of serum SCCA,CA-199 and HPV in cervical cancer and precancerous lesions

Objective It is to study the clinical value and significance of serum levels of squamous cell carcinoma antigen(SCCA),carbohydrate antigen-199(CA-199) and human papilloma virus(HPV16/18) infection in patients with cervical cancer and precancerous lesions.Methods The expression of SCCA,CA-199 and HPV was detected in 150 patients with cervical intraepithelial neoplasia(CIN) and 100 cases with cervical cancer,and the relationships of these indexes with histological type,clinical stage,differentiating degree,tumor stage and metastasis of lymph node were observed.Results With the increase of CIN grade,the expression of HPV,serum SCCA and CA-199 gradually increased(P<0.05),the expression of human papillomavirus,SCCA and CA-199 in cervical cancer was significantly higher than those in CIN.The expression of HPV had no correlation with pathological type,clinical stage,histological differentiation,tumor type,and lymph node metastasis(P>0.05).The expressions of serum SCCA and CA-199 had obvious correlations with clinical stage,histological differentiation and lymph node metastasis,but they were not correlated with tumor type.Distinctly,the expression of SCCA was related to the histological type,but CA-199 was not related to the histological type.Conclusion Comprehensive analysis of the expression of serum SCCA and CA-199 and HPV could provide the guideline for the diagnosis and clinical evaluation of the patients with cervical cancer.