血清性激素水平与老年男性认知功能相关性研究

目的探讨老年男性血清性激素水平与认知功能的关系。方法选取2008年12月至2009年12月间在第六人民医院老科就诊的老年患者62例采用简易智能量表（MMSE）评估认知功能，男性患者按照MMSE测定分数分为认知功能正常组（30例）与认知功能障碍组（32例）。采用化学发光法测定所有患者血清总睾酮（TT）和性激素结合球蛋白（SHBG）及雌二醇（E2）水平，并根据Vermeulen公式计算游离睾酮（FT），比较两组患者TT、E2和FT水平的差异，并分析TT、E2、FT与老年认知功能的相关性。结果老年男性中认知功能障碍组的雌二醇[（20．88±5．10）pmol／L vs（27．00±9．61）pmol／LP〈0．05]、总睾酮[（4．52±1．88）mmol／L vs（6．42±1．84）mmol／L P〈0．05]、游离睾酮[（0．043±0．022）nmol／L vs（0．092±0．034）nmol／L P〈0．05]水平较认知功能正常组低（P〈0．05）。结论老年男性认知功能障碍可能与性激素水平下降相关。

The relationship between the serum sex hormones and cognitive impairment in elderly men

Objective To explore the relationship between the free testosterone and cognitive impairment in elderly men. Methods The cognitive function of 62 men aged≥ 60 years were tested with Mini Mental State Examination （MMSE）. The samples were divided into two groups based on MMSE scores： the normal cognitive group （ n=30 ） and the impaired cognitive group （n=32）. The serum sex hormones such as estradiol, total testosterone and SHBG were measured with determination, and in accordance with Vermeulen formula to calculate free testosterone （FT）, then compared the difference of the levels of TT, FT and E2 in two groups of patients. And the dependency of TT, E2, FT and cognitive function in old age were analyzed. Results The levels of serum estradiol, free testosterone and total testosterone in the impaired cognitive group were significantly lower than those in the normal cognitive group （P〈0.05）. Conclusion The cognitive impairment may be associated with the decline of testosterone.