Snail与E-cadherin在上皮性肿瘤中的表达及其临床意义

目的:探讨Snail与E-cadherin蛋白表达在上皮性肿瘤中的临床意义。方法:应用免疫组织化学SP法,研究150例人肝癌、乳腺癌、宫颈癌、子宫内膜癌与卵巢癌临床标本及30例相应正常组织中Snail与E-cadherin蛋白的表达及定位。结果:在上述5种组织中,Snail主要表达于癌组织细胞核、细胞质,相应正常组织往往缺如,且在肝癌、乳腺癌中Snail表达与肿瘤转移有一定的相关性,并与E-cadherin表达呈负相关。E-cadherin定位于细胞膜,在肝、乳腺的正常组织中E-cadherin强表,相应癌组织中其表达往往下降或缺如;而在宫颈癌、内膜癌与卵巢癌中,E-cadherin表达与癌变无明显相关性。结论:Snail、E-cadherin的表达在肝癌、乳腺癌中具有重要意义,Snail有可能作为肝癌、乳腺癌肿瘤转移的生物学标志。

Expressions of Snail and E-cadherin in epithelial carcinomas and their clinical significance

Objective:To examine the expression of Snail and Ecadherin protein in human glandular and epithelial carcinomas and the clinical significance.Methods:Immunohistochemical SP method was used to assess the expressions of Snail and E-cadherin protein in 150 cancerous samples of human liver,breast,cervical,endometria,and ovary tissues and 30 corresponding normal tissues.Results:Snail located mainly in nucleus and plasma of cancer cells.Snail protein had higher expression in cancerous tissues of liver,breast,cervix,endometrium and ovary and had almost no expression in normal tissues.Opposite with E-cadherin,Snail had higher expression in liver and breast carcinoma which was negatively associated with the metastasis of liver and breast carcinoma.E-cadherin located mainly in membrane and plasma of cells.E-cadherin had higher expression in normal liver and breast tissues but had lower or no expression in corresponding cancerous tissues.The expression of E-cadherin was not associated with cervical,endometrial and ovarian cancers.Conclusion:The expressions of Snail and E-cadherin had clinical significance in liver and breast carcinoma.Snail has the potential to be the biological marker indicating the metastasis of liver and breast carcinoma.